Variation of dengue NS1 antigen measured by commercial ELISA kit in various forms of dengue infections and assessment of the association between NS1 antigen level and disease severity
نویسندگان
چکیده
Background Dengue is a systemic infection with a wide clinical spectrum including asymptomatic, mild undifferentiated dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue with shock syndrome (DSS). Detection of dengue NS1 antigen (Ag) in acute infection is a valuable tool for early diagnosis. The purpose of this study was to evaluate the sensitivity of the Platelia NS1 Ag kit (BioRad®) for the various forms of DENV infection and assess the potential role of NS1 Ag as a marker of severity.
منابع مشابه
Clinical and Virological Factors Influencing the Performance of a NS1 Antigen-Capture Assay and Potential Use as a Marker of Dengue Disease Severity
BACKGROUND Detection of dengue NS1 antigen in acute infection has been proposed for early diagnosis of dengue disease. The aim of this study was to evaluate the clinical and virological factors influencing the performance of the Platelia NS1 Ag kit (BioRad) and to assess the potential use of NS1 antigen and dengue viral loads as markers of dengue disease severity. METHODOLOGY/PRINCIPAL FINDIN...
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